tirzepatide obesity trial non-diabetic surmount-1 weight loss percentage For the first time, tirzepatide and semaglutide were put in the same trial. SURMOUNT-5. Phase 3b RCT. 751 adults with obesity, no diabetes. 72 weeks. Both drugs at maximum tolerated dose. The
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A 2025 JAMA Network Open study matched ~60,000 adults and followed them 7 years. Those on semaglutide or tirzepatide had about 37% lower dementia risk, strongest in women, those over 60, and higher ...
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